Category Archives: Asked & Answered

Asked & Answered 17.0

I was an amateur inventor of games from my childhood to mid-adulthood.  Looking back,  all my games were way too lame for anyone but close friends to accede to play.  That they did so anyway (as some readers may remember!) makes me both wince and smile.*

For some odd reason — especially odd because the last time I attended a party was over a decade ago — I was recently inspired to think up a dice-based party game.  I’ll call it POP!

The party-attendees/players would be divided into teams.  Each team would, in their turn, toss a set of dice that would specify a pop-culture question to be answered — for example, name a film with a three-word title that starts with P.  The dice decide the category (film), the number of words in the answer (three), and the first letter of the answer (P).

[Aside: Did you just now pause to rack your brain for films with three-word titles starting with P?  If so, my apologies, because the only one I came up with — in desperation — was Peter the Great (USSR, 1937).  This shows why POP! should be played by teams and then strictly adjudicated by Wikipedia.]

There would be a time limit for the team to answer, to keep the game moving along and to afford the chance of failure.  The team would score points (“POP”) if it came up with an answer within the allotted time, and nothing (“PLOP”) otherwise.  Answers could only be used once a game.

In POP!, the arts category would be selected by a six-sided die with the faces FILM – TV – PLAY – MUSIC BOOKANY.  If the player rolls ANY, the team may choose any form of art or entertainment including those (say POETRY or BALLET) not shown on the die.

The number of words in the team’s answer would be chosen by another six-sided die with the faces 1 – 2 – 3 – 4 – 5 – ANY.  Since long titles are rarer and harder to recall, the team’s score (if successful) would be based on the number of words in the title — say, 10 points a word, with a 10-point bonus for five-plus words.  So, One Flew Over the Cuckoo’s Nest would be a very profitable film or book answer if the team’s starting letter was O.

Which brings us to the matter of deciding the starting letter, and my impetus for writing this article.  The challenge of an amateur game-designer like me is how one might “best” use a die or dice to select a letter from the 26-letter English alphabet.  (I will touch upon what “best” means as we go along.)

Selecting a starting letter would be trivial if we were simply content to ask a computer, “Pick a number from 1 to 26 and name the corresponding letter of the English alphabet.”  But that computation takes place deep inside some data center where no light penetrates.  Humans don’t trust results that emerge from the dark — we like to see physical processes play out, to convince ourselves of their “fairness.”  This is how humans came to use solid, scrutable objects like dice to turn chance into outcome.

Enough Already!  Just Use a 26-sided Die!

The first and most obvious solution is for POP! players to roll an object that resembles an ordinary die except that it has 26 faces, with letters printed on the faces.  You can even buy such dice on Amazon:

Problem solved, we’re done here, yes?  Well, yes, if I were anyone else but the unfortunate perfectionist I am.  The issue with dice like these is that they are intrinsically not fair — some faces come up more often than others, not that I can predict which ones.  But still…

Mathematicians have long known that only certain shapes qualify as fair.  The foremost of those are the five Platonic solids shown below, having 4, 6, 8, 12 and 20 faces:

Image Credit: www.technologyuk.net

Besides these, a group of solids known as isohedrons are also geometrically fair, but none happen to have 26 sides.  This means that alphabet letter-picking hairsplitters like me are out of luck when it comes to POP!  So what are my alternatives?

A.  Manufacture and spin a 26-sided teetotum

As I recently learned, a teetotum is a top with flat sides that commonly replaced dice in devil-phobic times and cultures.  The player spins the teetotum and reads the side that faces up when it comes to a stop.  Here are some examples, including the Jewish dreidel

So why not just make a 26-sided teetotum — or the equivalent, a 26-sided barrel-shaped object with a different letter on each face — then spin it (or roll it) and call it a day? 

Here’s-Why-Not No. 1:  A 26-sided object would be so smooth — 99% of a circle — that it might just roll around forever before it came to a stop (see cross-section below).

Dice-Tossing Principle No. 1:  A die must eventually come to a stop.

Here’s-Why-Not No. 2:  Size and readability.  In order to read a 26-sided teetotum or barrel-shaped die, each face would need to be about 1/4-inch tall — which means the object that you spin or roll would be more than two inches in diameter.  Come on.

It is my opinion, as a grizzled game-inventor, that such an object would be far too clunky (not to say inelegant) to do the delicate job of selecting a letter from the English alphabet.  Who’s with me on this?  Let’s find a better way.

B.  Use fair die/dice with extra faces and discard some outcomes

If a 26-sided die isn’t fair and a 26-sided barrel-shaped die is too clunky, then POP! could use dice of other shapes, alone or in combination, to pick the starting letter.  One option is the rhombic triacontahedron, a fair D30 (short for 30-sided die) made by Koplow Games

Conveniently for our purposes, this die is imprinted with the 26 letters of the alphabet plus four “wild” faces, and it is not clunky — at 1.25 inches diameter, the die is about the size of a plump cherry tomato, or the “OK” circle you make with your thumb and forefinger.

Although this die is fair, its wild faces work against our original goal, to ensure each letter has an equal chance of being selected.  If we stick to that principle, then a player who rolls a wild should have to re-roll.  This would mean 2 re-rolls every 15 tosses — inconvenient, yes, but not an overwhelming burden for purists like me.

Even so, POP! could have a rule that a player could pick any starting letter if he/she rolled two wilds in a row.  (There’s less than a 2% chance of that on any turn.)  This would be a lemonade-from-lemons kind of rule, and why not.

C.  Use six-sided alphabet dice with a selector

You can buy nicely-designed six-sided alphabet dice like these on Amazon and elsewhere:

Such dice may be pleasing to roll but they leave something to be desired for POP! players.  First off, this set of dice has the same issue as the D30 we just discussed — four of the faces have no letter and thus would require a re-roll.  Secondly, and more to the point, there’s no obvious way to select one letter out of the five letters facing up.

I can think of a few creative ways to select one of the five letter dice:

  • Toss the dice against a backboard, then select the die that comes to rest closest to the backboard, provided some dice bounce back.  (And assuming you have a long table.)
  • Paint the letter dice different colors, then roll a blank multi-color die to select the letter die that shares that color.  (More design, more cost, see below.)
  • Use a spinner to select one of the five dice.  (But I thought this was a dice game!)
  • Pull a die at random out of a bag and roll that one.  (One more accessory!)
  • Toss all the dice in the air, and have another player grab one and roll it.  (Dangerous!)
  • Put all the dice in your mouth, then spit one out onto the table.  (Ick!)

In the end, six-sided letter dice involve too much chaos — rolling a D30 is much simpler, so that’s the solution I would favor, even with the occasional re-rolls.

Also, putting all the dice in your mouth would be a choking hazard and I would get sued.

D.  Or, one last variation…

Maybe the real problem here is my insistence that each letter have an equal chance of being selected.  If rolling an X, Q or Z always results in a plop, how much fun is that?

So here’s my final proposal — in this version, the player will use three D8 dice, not much larger than D6 dice, to select the starting letter of the answer.  This reduces the volume of dice tossed, makes play a bit easier, and offers fun elements of both chance and choice.  (What more could one ask for — world peace?)

We will fit the 26 alphabet letters on the 24 die faces of those D8’s by combining X and Z on one face and Q and V on another face.  We will also dispense with the selector die — instead, we will let the player choose any of the three face-up letters as the starting letter. Why make the game more difficult than it already is?

Now, as to making the game: I can procure the custom dice and dice cup shown here, plus a toy hourglass, for around $90 on Etsy.  While I could print my own labels and glue them onto blank dice, the game would look amateurish and nobody will play it — as opposed to looking slick and professional and nobody will play it.

I think I’ll save my money.

So, let’s raise a cup of imaginary dice to another one of my fantasy games — POP!

Appendix: The Messy Details

I glossed over a few design details and play mechanics that I would need to address before the game was played for its first and only time.  The most important of these questions is, how to deal with titles that start with A, An or The.  Example: whereas Sopranos feels like an acceptable alternative to The Sopranos, I don’t feel the same about The Way We Were. Sometimes the leading article seems integral to the title, sometimes not.

In an attempt to settle this, I consulted the National Film Registry Listing maintained by the Library of Congress.  Their listing is sorted alphabetically, and they alphabetize titles according to the word that follows the article.  So The Wizard of Oz is a four-word entry among the other W entries, as if the The wasn’t there, except that it is.

OK, but POP! needs explicit, written rules.  I would rule that The Sopranos starts with S, but your answer could be one word (Sopranos) or two (The Sopranos).  The same goes for The Way We Were — a W title that has either three or four words, depending on whether you include the The in your answer.  This bugs me, but I can live with it.

This brings me to how to design the three D8 letter-dice so that an “interesting” array of starting letters is offered to the player.  I wouldn’t want all of the most-common starting letters to be on the black die and all the least-common on the blue die — no one would ever select the blue die.  It would be more fun if the letter choice varied in difficulty depending on how the dice were rolled.

This called for research on my part as to the most-common starting letters in the titles of works of art.  Since it is impossible to list and alphabetize the titles of all works of art ever created, I used the Library of Congress film registry as a representative (get it?) sample.  The chart below shows how those film titles are distributed:

I was surprised to see S, M, B and T were the four most-common starting letters, but was not surprised that Z, Y, Q and V were the least-common — except X, which did not appear at all, not a tiny bit.  Had I surveyed song titles along with films, I’m sure there would have been many more titles starting with I (for I) and (for You), but the film title order was a good enough starting point for me.

So here is how I would design the three D8 letter dice to offer variety in difficulty level:

Your odds of rolling the XZ/U/QV combination (or any other combination for that matter) would be 511-to-1.  Pretty high odds, but your opponents would be rooting for this combo every time you roll.

The last little detail I have yet to figure out is how the game ends.  I think the best way is, when everyone gets tired of it.  That way, like the idea itself, it can stop before it begins.  

___________________

* My game-creation efforts reached their peak (or nadir, they might say) on our workgroup’s dealer-choice poker nights.  My most infamous poker-night game was called “Brain Trust”, a seven-card-stud variant which paired up players and their hands based on matching up-cards.  My fellow players continued to deal “Brain Trust” long after I became too bashful to call the game myself — perhaps to further embarrass me.
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Asked & Answered 16.0

Here is a banquet table of cerebral cooking for your Thanksgiving enjoyment. Spoon out a serving or three and let them melt in your mind.  Answers revealed down the road…

1A tireless Thanksgiving traveler drove 3,340 miles east, then 377 miles north, then another 3,340 miles east, then 377 miles south, only to find himself back where he started.  How much time did he spend texting-while-driving?

2I have a vivid memory of the time, early in my Kodak career, that a research scientist explained to me how “yellow is not a color.”  I was crushed — yellow is my favorite! — but what did he mean?  And why was he so damn dogmatic about it?

3How much ice cream would you have to eat to cause your entire brain to freeze?

4In the game of 8-ball, 15 billiard balls are arranged in a triangle, with a ball at the apex, two balls nested behind it, three balls behind those, etc.  The 8-ball (black) is placed in the center of the middle row — in the #5 spot — to reduce the chance of sinking it on the break (see image).  But the 8-ball is not perfectly centered, as it does not occupy the #8 spot in the rack.  (The image shows a 3-ball in that spot.)

If we were to consider racks of more than 15 balls, could we find a triangular rack in which the middle-numbered ball, i.e., the black ball, could be placed in the center of its row and in its own numbered spot?

Consider a six-row rack.  It would have 21 balls, and the 11-ball would be the “black” ball.  We would want the 11-ball, when placed in the #11 spot in the rack, to be in the center of its row, behind the apex ball.  This particular case does not work, but you get the idea.

I have fun memories of Thanksgiving 8-ball games at our children’s grandparents’ house.

5Of the 50 U.S. states, do any two adjoin each other geographically and alphabetically?  If not, what’s the closest such approach?  Thanksgiving travelers want to know.

6Just for fun, let’s expand the question posed in (5) to the nations of Europe, although Europeans (and Jehovah’s Witnesses) do not celebrate Thanksgiving.

7In the “Hole in One” game on The Price is Right, contestants have to rank six items from least expensive to most expensive, after which they make a short putt to try to win a new car.  Now, here is your chance to win a car and drive it hundreds of miles or more to see your loved ones on Thanksgiving.  Rank the items below from least to most expensive.  Score $5,000 whenever an item in your list is more expensive than all the previous items in your list.

(a) One Space-X launch

(b) One year’s compensation for Barry McCarthy, CEO of Peloton

(c) The annual U.S. budget for gun violence research

(d) The annual U.S. military expenditure for Viagra

(e) The world’s oldest (1100 years) Hebrew Bible

(f) Oprah Winfrey’s Montecito, California mansion

8At precisely 11 o’clock on Thanksgiving night, the angle between the two hands of an analog clock is exactly 30 degrees.  How soon, if ever, will the hands form the same angle?

9“Over the river and through the wood, to Grandmother’s house we go,” goes the verse.  Question:  What happened to Grandfather?

(a)  Got trampled by the horse.

(b)  Got run over by the sleigh.

(c)  Got lost in the white and drifted snow.

(d)  Got bumped off by Grandmother in the 1890s.

 


Okay, I promised answers, and here they are.  Brace yourselves.

1A person who drives 3,340 miles east, 377 miles north, another 3,340 miles east, then 377 miles south to return to his starting point, is likely to be on the surface of a body that is 6,700-plus miles in circumference.  The most likely candidate is the Earth’s Moon. 

Our holiday traveler started his journey at 10° South lunar latitude.  The first eastward leg of his trip took him halfway around the moon.  The second leg took him from 10° South to 10° North.  The third leg completed his circuit around the moon.  The fourth and final leg returned him to 10° South, where he started.

So the answer to how much time he spent texting-while-driving is 50 percent.  Being that one side of the moon always faces Earth and the other side never does, he would have spent exactly half his journey on the Earth-facing side.  Our answer presumes constant speed, no communication from the “dark side” of the moon, and the human proclivity to be on one’s phone at all times.

And after all that, the turkey was still frozen.

2I was told by one photo-chemist that yellow was not a “color” but instead a “response” created in one’s brain by the stimulation of a particular ratio of red- and green-sensitive receptors in the cones of our retinas.  In his view, the only “true” colors were red, green and blue, with every other hue simply products of our mind.  I wasn’t really swayed by his reductionist argument then and I remain unconvinced now.  If “yellow” is meaningless, then so is “hot” (a sensory combination of “cold” and “warm” signals) and who knows how many other states-of-mind.

Why was this photochemist so dogmatic about yellow?  Well, he was the kind of scientist Kodak hired aplenty, persons who thought silver-based technology was just so good that everyday people did not even begin to appreciate its quality, and then felt shocked — even betrayed! — that fateful day when those everyday people decided that mediocre-but-free digital photos were just as useful as expensive shot-on-film and printed-on-paper ones.

3How much ice cream would one have to eat for your entire brain to freeze?  May I say,  this is a freshman chemical-engineering kind of problem, or it was when I went to college and did some chemical engineering on my own brain.  An average adult brain weighs 3 lbs and is maintained at a temperature of 98.6°F.  To make it freeze, one first has to cool the brain from 98.6° to 32° (this is called sensible heat though it has nothing to do with being sensible) and then extract additional heat (called latent heat even though it isn’t hiding anywhere) to turn the brain’s water into ice.

If we assume the brain is almost entirely water (Trump’s brain is a mix of rocks and air, so this doesn’t apply to him), then the sensible heat part would be Qs = m·c·ΔT or, the mass of the brain times the heat capacity of the brain (i.e., water) times the temperature change. In BTU (I British Thermal Units), this would be 3 lb x 1 BTU/lb/degree x 66.6 degrees or 199.8 BTU.  Let’s just call it an even 200 BTU.  And aren’t you glad this paragraph is over.

The latent heat needed to freeze 1 lb of water at 32°F is 144 BTU (just a fact of nature), so it will take 432 BTU to crystallize a 3 lb adult brain.  This means the total heat that must be extracted to cause brain freeze is 632 BTU.

Ice cream also has sensible and latent heat.  Ice cream must first warm up from, let’s say, 5° to 32° (absorbing 27 degrees worth of sensible heat) before it can melt, via latent heat. We need to equate the heat needed to melt ice cream with that needed to freeze a brain, and here is that equation (where M is the unknown mass of ice cream):

632 BTU = M · 1 BTU/lb/F · 27F  +   M · 144 BTU/lb

The solution to this equation is M = 3.7 lbs ice cream.  Since water weighs 8.34 lbs/gallon, this would be equivalent to 0.44 gallons of air-free ice cream.  However!  Being that most ice cream is 45% air (if you learned anything here, let it be that), one would need to ingest 0.44 / (1 – 0.45) = 0.8 gallons of direct-from-the-carton ice cream to produce a total brain freeze, if all the heat needed to melt the ice cream came directly from your brain.

Moral: Don’t even think about opening that second half-gallon.  Unless you’re Trump, and in that case, what more harm could it do?

4Billiards and recreational mathematics.  I didn’t think I would be getting this deep when I posed this question, but too late now.  We are looking for a triangular number of the form n = r(r+1)/2, where n is the total number of balls, r is the number of rows in the rack, and the numerically-middle “black ball” — number (n+1)/2 — is located in the middle of its row (i.e., behind the apex ball) and in its numerical-order spot in the rack.

The first thing we should note is that n, the total number of balls, must be odd, being that the black ball divides the set of balls into equal groups of solids and stripes.  Furthermore, the numerically-middle black ball must be, by necessity, in an odd-numbered row for it to be in the center of its row.

The only “black ball” numbers that qualify based on these criteria are the centered square numbers (c = 1, 5, 13, 25, 41, 61, etc. …) as illustrated in this diagramThe formula is c = [(r+1)^2  + (r-1)^2] /4 where r is one of the odd rows of the billiards rack.

At this point, I decided the easiest thing to do was to generate a list of triangular numbers (n) and a list of the centered square numbers (c), and look for any cases where c = (n+1)/2. In such cases, the black ball would be centrally-located both numerically and positionally.

I found one such case and then stopped looking.  The solution I found is n = 1,225 balls, arranged in a 49-row rack.  Ball #613 is numerically in the middle, is positioned centrally in the rack, and occupies the 613th spot in the rack.  Below is a diagram of this rack, with Ball #613 painted black.  I dare you to break!

5Two pairs of U.S. states are adjacent both alphabetically and geographically:  Florida-Georgia and Illinois-Indiana.  Iowa-Kansas is a near (40 miles) miss.

6With respect to European nations, my first thought was that Estonia-Finland were a doubly-adjacent pair, but that is not the case — while they both border the Gulf of Finland,  their territorial waters do not meet.  However!  If we instead consider the endonyms of the European nations — i.e., how they refer to themselves in their own language — then there are two such doubly-adjacent nations:  Danmark-Deutschland (Denmark-Germany) and Suomi-Sverige (Finland-Sweden).

7Our six Hole-in-One items, from least expensive to most expensive:

  • The annual U.S. budget for gun violence research: $25 million
  • The world’s oldest (1100 years) Hebrew Bible: $37 million
  • The annual U.S. military expenditure for Viagra: $41 million
  • One Space-X launch: $67 million
  • Oprah Winfrey’s Montecito, California mansion: $90 million
  • One year’s compensation for Barry McCarthy, CEO of Peloton: $168 million

If you ranked all of these items in the correct order, then please go out and buy whatever brand new car you want.

8After 11:00:00, the next time the clock hands will form a 30 degree angle is 11:54:33.  (I didn’t say that the hour and minute hands had to be in the same relative position.)  Credit to onlinetools.com for making this problem easier to solve.

9The poem “The New-England Boy’s Song about Thanksgiving Day” was penned by Lydia Maria Child in 1844.  In her original version, the visitors were in fact headed to Grandfather’s house.  But in the 1897 “Prang Primary Course in Art Education,” Mary Dana Hicks refers to it, for the first time I can document, as Grandmother’s house.  Clearly, something unsavory befell Grandfather around then, and I blame Grandmother.

May you all have a safe and happy Thanksgiving in whomever’s house you spend it.

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Asked & Answered: 15.0

The majority of my readers (I would say vast majority but that would imply a vast number of readers) are of, shall we say, advanced age.  Being of advanced age has its benefits — for instance, my age allows me to completely ignore what passes for pop music these days and no one, except maybe James Corden, will criticize me for it — but advanced age also has its drawbacks.  One of them is the ever-growing list of prescription drugs that people my age find themselves ingesting on a regular basis.

Don’t get me wrong, I’m not anti-medical-science.  In fact I feel fortunate when I consider the array of drugs developed in the last 40, 30, 20, 10 years to address the many maladies of civilized life.  These drugs range from lisinopril (high blood pressure, approved in 1987, generic since 2002) to omeprazole (acid reflux, approved in 1988, generic since 2001) to ropinirole (restless legs, approved in 1997, generic since 2008) to aflibercept (wet macular degeneration, approved in 2011 and now costing Medicare $2.9 billion a year) to apixaban (anti-coagulant for atrial fibrillation, approved in 2012 and costing $10 billion a year).

Being of suitably advanced age and other circumstances, I partake of all of these drugs, and more.  Not like it’s fun, but it would be less fun otherwise.

But what I really want to talk about is how these wondrous pharmacologicals are handled inside our bodies.  We down these pills as if they simply melt in our tummies, magically do their respective jobs for the day, and then discreetly leave the scene.  But that would not be the case at all.

I became interested in how drugs are processed in our bodies after a recent, and brief, trial of the diuretic chlorthalidone, a blood-pressure medicine that has been in use since 1960.  In my case, the drug is unreasonably effective.  In just two days, my blood pressure fell nearly 30 points and I lost about 6 pounds, despite drinking lots of water to stay hydrated.  I had to stop the trial to keep my blood pressure and weight from falling even further.

I wondered how chlorthalidone could have such a drastic, powerful effect on me — could there have been some interaction with another of my several prescription medicines?

• • • 

When drug interactions occur, it’s not because the drugs chemically react with one another in your bloodstream, but typically because they (a) have the same effect, (b) have opposing effects, or (c) use the same metabolic path through your gut or liver– in effect, competing with each other for your body’s metabolic resources.  This is actually pretty common.

Another type of interaction is when you ingest something, drug or otherwise, that thwarts the metabolic process itself.  You’ve probably heard, for example, that drinking grapefruit juice is a bad idea when you are taking certain medications.  This is because…

… grapefruit juice inhibits the CYP3A4 enzyme of the cytochrome P450 system in the intestinal mucosa, increasing the bioavailability of drugs with a high first pass metabolism. [British Journal of Medical Practitioners, 2012]

If I may clarify — and please do, you say!  According to the National Library of Medicine, CYP3A4 is the name of a gene on human chromosome 7.  This gene directs various cells to manufacture an enzyme (one of the P450 enzymes) that is “involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin, diazepam, erythromycin, and chloroquine.  The enzyme also metabolizes some steroids and carcinogens.”

Here, metabolism means the process of breaking down a drug into smaller molecules that can be eliminated by the body.  Simply put, the CYP3A4 enzyme helps us deactivate many toxins and drugs.  In fact, drug manufacturers rely on CYP3A4 to remove their drugs from the bloodstream, which allows medicines to be taken on a daily, high-compliance basis.

If your CYP3A4 enzymes get blocked or disabled, then the drugs that are designed to be broken down by CYP3A4 will circulate in your system at higher levels than the drug-maker intended.  This can in turn produce toxic effects.

The CYP3A4 enzyme (below, per the RCSB Protein Data Bank) looks like a Rorschach test designed by Jackson Pollock:

Drawing of CYP3A4 enzyme

That mammals, over the eons, evolved a way to manufacture a toxin-neutralizing enzyme as complex as this is beyond my comprehension — and also beyond the scope of this post. But clearly, the evolution of CYP3A4 wasn’t shaped by grapefruit juice.  (The chemical in grapefruit juice, bergamottin, that deactivates the CYP3A4 enzyme was not conclusively identified until 2012.)

Grapefruit juice is not the only inhibitor of CYP3A4 (see this list) and is only one of many food-based inhibitors (fresh-ground black pepper is another).  I don’t use much pepper or drink grapefruit juice, so that would not explain any unusual drug responses I might have.  It would be more likely for my medications to be fighting over my CYP3A4 enzymes.

Curious, I made a list of the 11 (yes, that many) medications and supplements that I take on a daily and/or occasional basis, and then searched the web to see how many of them use the CYP3A4 pathway.  I found that 6 of the 11 rely on CYP3A4 for their metabolism, and two of those can even inhibit CYP3A4.  Just to complicate things.

I have no control which drugs have first dibs on my CYP3A4 reserves.  I guess I have to trust that, if I’m not having issues, then my body is doing its best to handle the drug traffic down there.  But it pays to be vigilant, especially when adding or adjusting medicines.

• • • 

What about my not-so-friendly friend, chlorthalidone?  Turns out that CYP3A4 was not a factor here — chlorthalidone is hardly metabolized at all but instead is very slowly filtered out by the kidneys.  By slowly, I mean that it takes over 40 hours to eliminate half of it.

This is probably one reason why, as I just learned, that diuretics like chlorthalidone are on the American Geriatric Society’s Beers List of “potentially inappropriate drugs” for older (sorry, advanced age) adults.

I know now that the dosage of chlorthalidone I was prescribed (25mg) was way too high; as I discovered, it would have been more prudent for my doctor to have started me out on one-quarter of that dose, given my age.  Doctors know a lot of things, but they can’t keep up with everything.  It doesn’t mean you doubt them, but you have more time and energy to research your specific situation than your doctor does — you can add to her knowledge.

If this post has given you a slightly better sense of what goes on inside you after you take your pills, and helps you appreciate the complexities of medical management for seniors, then great.  Thanks for hanging in here until the end.

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